Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31470897 | 1.00 | GPR119 (0.46) | GPR119ARPARP1NR1H2NR1H3 | |
| SCHEMBL25913721 | 0.86 | DPP4 (0.47) | PARP1NR1H2NR1H3 | |
| SCHEMBL3697218 | 0.86 | DPP4 (0.47) | PARP1NR1H2NR1H3 | |
| SCHEMBL30741064 | 0.86 | GPR119 (0.46) | GPR119ARPARP1NR1H2NR1H3 | |
| SCHEMBL8140446 | 0.85 | PARP1 (0.43) | PARP1NR1H2NR1H3 | |
| SCHEMBL1673503 | 0.85 | MEN1 (0.43) | PARP1NR1H2NR1H3 | |
| SCHEMBL28304239 | 0.85 | NR1H2 (0.50) | PARP1NR1H2NR1H3 | |
| SCHEMBL21001077 | 0.85 | GPR119 (0.52) | GPR119ARNR1H2NR1H3JAK2 | |
| SCHEMBL22285173 | 0.85 | NR1H2 (0.49) | GPR119PARP1NR1H2NR1H3 | |
| SCHEMBL4325057 | 0.85 | NR1H2 (0.49) | GPR119PARP1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1764650-B | 2, 3, 6-trisubstituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP | 2010-06-16 | — | — | CN | disclosed |
| CN-1976935-A | Pyrazolo- [4, 3-e]-1, 2, 4-triazolo- [1, 5-c]-pyrimidine adenosine A2AReceptor antagonists | SCHERING CORP (US) | 2007-06-06 | — | — | CN | disclosed |
| CN-1764650-A | 2, 3, 6-trisubstituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP (JP) | 2006-04-26 | — | — | CN | disclosed |
| US-5607936-A | USEFUL IN TREATMENT OF RESPIRATORY DISEASES | MERCK & CO., INC. (US) | 1997-03-04 | — | — | US | disclosed |
| WO-1996010568-A1 | SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1996-04-11 | — | — | WO | disclosed |