Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8881624 | 0.84 | SIGMAR1 (0.43) | KDM4EALDH1A1GAAHPGDLMNA | |
| Oxalic Acid SCHEMBL8880863 | 0.83 | CNR2 (0.48) | KDM4EALDH1A1CNR1CNR2SMN1; SMN2 | |
| SCHEMBL2641012 | 0.73 | CFTR (0.56) | BRD4 | |
| SCHEMBL29200758 | 0.72 | HPGD (0.60) | CCR2KDM4EALDH1A1GAACNR1 | |
| SCHEMBL30783420 | 0.72 | HPGD (0.60) | CCR2KDM4EALDH1A1GAACNR1 | |
| SCHEMBL5166280 | 0.72 | TP53 (0.45) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL3300361 | 0.72 | CCR2 (0.52) | CCR2KDM4EUSP2ALDH1A1GAA | |
| SCHEMBL11536101 | 0.72 | CCR2 (0.66) | CCR2KDM4EALDH1A1GAACNR1 | |
| SCHEMBL30884510 | 0.72 | CCR2 (0.66) | CCR2KDM4EALDH1A1GAACNR1 | |
| SCHEMBL3295174 | 0.70 | F10 (0.49) | CCR2KDM4EUSP2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691341-A | ANTILEUKEMIA AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0623598-A1 | APOPTOSIS REGULATOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-09 | — | — | EP | disclosed |