Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8882079 | 0.84 | CCR2 (0.49) | SMN1; SMN2LMNAALDH1A1HPGDKDM4E | |
| Oxalic Acid SCHEMBL8880863 | 0.77 | CNR2 (0.48) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18171802 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1127697 | 0.71 | PPARG (0.58) | SIGMAR1TMEM97HTR1AADRA2AADRA2B | |
| SCHEMBL8694830 | 0.70 | MEN1 (0.69) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5320439 | 0.68 | ALDH1A1 (0.58) | SMN1; SMN2LMNAALDH1A1HPGDMEN1 | |
| SCHEMBL5166280 | 0.67 | TP53 (0.45) | LMNAALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL27757481 | 0.67 | SRC (0.47) | SIGMAR1TMEM97HTR1AADRA2AADRA2B | |
| SCHEMBL7809208 | 0.67 | HTR1A (0.53) | SIGMAR1TMEM97HTR1AADRA2AADRA2B | |
| SCHEMBL3298363 | 0.67 | F10 (0.48) | SIGMAR1TMEM97HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691341-A | ANTILEUKEMIA AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0623598-A1 | APOPTOSIS REGULATOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-09 | — | — | EP | disclosed |