Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.48 |
| ▸ | CNR1 | P21554 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8882079 | 0.83 | CCR2 (0.49) | CNR2CNR1ALDH1A1KDM4EMAPT | |
| Oxalic Acid SCHEMBL8881624 | 0.77 | SIGMAR1 (0.43) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL31202584 | 0.74 | CNR2 (0.52) | CNR2CNR1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL7591962 | 0.73 | TLR8 (0.54) | CNR2CNR1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL18575786 | 0.73 | DAO (0.58) | CNR2CNR1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL5166280 | 0.72 | TP53 (0.45) | ALDH1A1KDM4EMAPTHTTMAPK1 | |
| SCHEMBL10762525 | 0.72 | ALDH1A1 (0.63) | CNR2ALDH1A1CYP1A2 | |
| SCHEMBL8242370 | 0.72 | ALDH1A1 (0.63) | CNR2ALDH1A1CYP1A2 | |
| SCHEMBL6682164 | 0.71 | ALDH1A1 (0.64) | CNR2ALDH1A1CYP1A2 | |
| SCHEMBL30277975 | 0.70 | PIK3CD (0.45) | CNR2CNR1ALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691341-A | ANTILEUKEMIA AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0623598-A1 | APOPTOSIS REGULATOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-09 | — | — | EP | disclosed |