Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | F13A1 | P00488 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 6/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884163 | 0.82 | KDM4E (0.48) | KDM4EF13A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9002107 | 0.76 | SMN1; SMN2 (0.53) | KDM4ESMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL10592850 | 0.74 | KDM4E (0.84) | KDM4EF13A1SMN1; SMN2MTNR1AALDH1A1 | |
| SCHEMBL8882957 | 0.74 | TBXA2R (0.56) | KMT2AMEN1 | |
| SCHEMBL9002411 | 0.74 | TRPV1 (0.51) | KDM4ESMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL10066080 | 0.74 | KDM4E (0.66) | KDM4EF13A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11040313 | 0.72 | KDM4E (0.51) | KDM4EF13A1SMN1; SMN2KMT2AMTNR1A | |
| SCHEMBL10969548 | 0.71 | RORB (0.60) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL11350077 | 0.70 | TRPV1 (0.49) | KDM4ESMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL11713261 | 0.70 | KDM4E (0.89) | KDM4EF13A1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681961-A | TREATMENT AND/OR PREVENTION OF THROMBOEMBOLIC DISORDERS, ARTERIOSCLEROSIS, METASTASIS. ISCHEMIA, ASTHMA, ALLERGIES | DR. KARL THOMAE GMBH (DE) | 1997-10-28 | — | — | US | disclosed |
| US-5426119-A | Thromboxane antagonists | DR. KARL THOMAE GMBH (DE) | 1995-06-20 | — | — | US | disclosed |
| US-5294626-A | Thromboxane synthesis inhibitors and anticoagulants | DR. KARL THOMAS GMBH (DE) | 1994-03-15 | — | — | US | disclosed |