Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | VCP | P55072 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | HPRT1 | P00492 | 10/20 | 0.46 |
| ▸ | PNP | P00491 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539282 | 0.88 | MEN1 (0.53) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL9539314 | 0.88 | MEN1 (0.53) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL9539258 | 0.88 | MEN1 (0.53) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL9019822 | 0.84 | MEN1 (0.48) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL2464875 | 0.84 | PDE3A (0.50) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL48362 | 0.81 | TK1 (0.51) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL1665132 | 0.81 | TK1 (0.47) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL6691912 | 0.81 | PNP (0.67) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| Ganciclovir SCHEMBL2160505 | 0.80 | BLM (1.00) | BLMALDH1A1SMN1; SMN2MEN1LMNA | |
| Ganciclovir SCHEMBL3033 | 0.80 | BLM (1.00) | BLMALDH1A1SMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648489-A | PREPARING 9-((1,3-DIHYDROXY-2-PROPOXY)METHYL)GUANINE FROM A PROTECTED GUANINE AND 2-ACETOXYMETHOXY-1,3-DIACETOXYPROPANE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) | 1997-07-15 | — | — | US | disclosed |
| US-5583225-A | REACTING N2, N9-DIPROTECTED GUANINE WITH DIACETOXYPROPANE IN THE PRESENCE OF A MIXTURE OF AN ACID AND ACETIC ANHYDRIDE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1996-12-10 | — | — | US | disclosed |