Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 11/20 | 0.40 |
| ▸ | HBB | P68871 | 2/20 | 0.37 |
| ▸ | PNP | P00491 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464875 | 0.85 | PDE3A (0.50) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL8884730 | 0.84 | BLM (0.67) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL9464079 | 0.81 | BLM (0.73) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL10994398 | 0.81 | ALDH1A1 (0.43) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL9019840 | 0.81 | HPGD (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2PDE3A | |
| SCHEMBL9019783 | 0.79 | ADORA2A (0.35) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL455760 | 0.77 | HPGD (0.41) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL9019776 | 0.77 | GDA (0.47) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL9539282 | 0.76 | MEN1 (0.53) | MEN1BLMKMT2AALDH1A1LMNA | |
| SCHEMBL9539258 | 0.76 | MEN1 (0.53) | MEN1BLMKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452680-B1 | Substituted purines, process for their preparation and their use as antiviral agents | HOECHST AG (DE) | 1996-11-06 | — | — | EP | disclosed |
| EP-0452680-A1 | Substituted purines, process for their preparation and their use as antiviral agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-23 | — | — | EP | disclosed |