Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8885573 | 0.85 | EGLN1 (0.48) | EGLN1GPR119FASNSMOMCHR1 | |
| SCHEMBL8885229 | 0.82 | F2 (0.40) | FASNMELK | |
| Hydrochloric Acid SCHEMBL8887677 | 0.82 | F2 (0.37) | MELK | |
| SCHEMBL8949169 | 0.77 | EGLN1 (0.43) | EGLN1GPR119MELKSMOKDM4E | |
| SCHEMBL8949164 | 0.77 | EGLN1 (0.43) | EGLN1GPR119MELKSMOKDM4E | |
| SCHEMBL8886068 | 0.71 | PDE4A (0.40) | MELK | |
| SCHEMBL8885770 | 0.71 | MCL1 (0.41) | MELK | |
| SCHEMBL9177754 | 0.70 | MAPT (0.49) | GPR119 | |
| SCHEMBL9185327 | 0.70 | ITGB3 (0.38) | — | |
| SCHEMBL8949132 | 0.70 | KCNH2 (0.43) | EGLN1GPR119KDM4EMMP2PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |