Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.43 |
| ▸ | MELK | Q14680 | 8/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8949164 | 1.00 | EGLN1 (0.43) | EGLN1MELKUSP30KDM1AKDM4E | |
| SCHEMBL8885573 | 0.80 | EGLN1 (0.48) | EGLN1USP30GPR119MAP4K4MINK1 | |
| SCHEMBL8885472 | 0.77 | EGLN1 (0.38) | EGLN1MELKKDM4EGPR119MAP4K4 | |
| SCHEMBL8949096 | 0.71 | MEN1 (0.46) | EGLN1KDM4EMAP4K4 | |
| SCHEMBL8949225 | 0.71 | CASP1 (0.43) | EGLN1KDM1AMAP4K4 | |
| SCHEMBL8949132 | 0.70 | KCNH2 (0.43) | EGLN1USP30KDM1AKDM4EGPR119 | |
| SCHEMBL8949110 | 0.70 | FASN (0.41) | EGLN1KDM1A | |
| SCHEMBL8949356 | 0.69 | TMPRSS15 (0.43) | EGLN1 | |
| SCHEMBL8949363 | 0.69 | TMPRSS15 (0.43) | EGLN1 | |
| SCHEMBL8948982 | 0.68 | EGLN1 (0.38) | EGLN1MELKKDM4EGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |