Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931186 | 0.87 | GAA (0.41) | HTTLMNAPOLBHPGDMAPK1 | |
| SCHEMBL20315227 | 0.86 | RAB9A (0.45) | HTTSMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL5339653 | 0.83 | LMNA (0.39) | HTTLMNAPOLBMEN1KMT2A | |
| SCHEMBL3785111 | 0.82 | CTSK (0.41) | LMNAALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL3785113 | 0.82 | CTSK (0.41) | LMNAALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL13785635 | 0.82 | CTSK (0.41) | LMNAALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6811831 | 0.79 | SMN1; SMN2 (0.51) | HTTSMN1; SMN2TSHRLMNAPOLB | |
| SCHEMBL10092627 | 0.78 | CYP17A1 (0.48) | HTTSMN1; SMN2BRD4 | |
| SCHEMBL14155353 | 0.78 | CYP17A1 (0.48) | HTTSMN1; SMN2BRD4 | |
| SCHEMBL17902833 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2TSHRLMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602277-A | Substituted benzene derivatives useful as neuraminidase inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| WO-1996030329-A1 | SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INCORPORATED (US) | 1996-10-03 | — | — | WO | disclosed |