Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8885863 | 0.72 | NPC1 (0.40) | HTR1BDRD2DRD3 | |
| SCHEMBL5738248 | 0.69 | HTR6 (0.59) | HTR6DRD2DRD3 | |
| SCHEMBL9670486 | 0.69 | HTR1D (0.54) | ADRA1AHTR1DHTR1BDRD2DRD3 | |
| SCHEMBL3205539 | 0.68 | HTR6 (0.71) | HTR6HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL10972396 | 0.67 | HTR1D (0.65) | ADRA1AHTR1DHTR1BDRD2DRD3 | |
| SCHEMBL7027637 | 0.65 | DRD2 (0.49) | HTR6DRD2DRD3 | |
| SCHEMBL7027642 | 0.65 | DRD2 (0.49) | HTR6DRD2DRD3 | |
| SCHEMBL9431901 | 0.64 | MTNR1A (0.36) | ADRA1AHTR1DHTR1BDRD2DRD3 | |
| SCHEMBL10978045 | 0.63 | HTR6 (0.60) | HTR6HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL17155340 | 0.62 | DRD2 (0.50) | ADRA1AHTR1DPLAUDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |