Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101152 | 0.85 | GABRA3 (0.60) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL8103073 | 0.77 | GABRA3 (0.59) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL8103362 | 0.76 | GABRA2 (0.65) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7328607 | 0.73 | GABRA2 (0.62) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7330178 | 0.71 | GABRA1 (0.75) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL8103365 | 0.70 | GABRA3 (0.62) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7328729 | 0.70 | GABRA1 (1.00) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL8094937 | 0.70 | GABRA3 (0.61) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL4895642 | 0.69 | KMT2A (0.51) | HSD17B10NPSR1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL8101160 | 0.68 | GABRA1 (0.55) | GABRA1GABRA2GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0547168-A1 | CERTAIN CYCLOALKYL IMIDAZOPYRIMIDINES, A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-06-23 | — | — | EP | claimed |
| US-5185446-A | Treating anxiety, sleep, seizure disorders | NEUROGEN CORPORATION (US) | 1993-02-09 | — | — | US | claimed |
| WO-1992004351-A1 | CERTAIN CYCLOALKYL IMIDAZOPYRIMIDINES, A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-03-19 | — | — | WO | claimed |
| US-5696260-A | AGONSIT, ANTAGONIST, PRODRUG; USEFUL IN DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP, SEIZURE DISORDER, OVERDOSE WITH BENZODIAZEPINE TYPE DRUGS AND ENHANCEMENT OF ALERTNESS | NEUROGEN CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| US-5426186-A | Diagnosis, treatment of anxiety, sleep and seizure disorders, benzodiazepine overdose; enhancement of alertness | NEUROGEN CORPORATION (US) | 1995-06-20 | — | — | US | disclosed |
| US-5185446-A | Treating anxiety, sleep, seizure disorders | NEUROGEN CORPORATION (US) | 1993-02-09 | — | — | US | disclosed |