Aminopterin

Aminopterin

SCHEMBL8887

Nc1nc(N)c2nc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cnc2n1

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 9/20 0.76
KDM4E B2RXH2 2/20 0.74
MEN1 O00255 2/20 0.74
ALDH1A1 P00352 2/20 0.74
TYMS P04818 2/20 0.74
POLB P06746 2/20 0.74
HPGD P15428 2/20 0.74
KMT2A Q03164 2/20 0.74
HSD17B10 Q99714 2/20 0.74
TDP1 Q9NUW8 2/20 0.74
GAA P10253 1/20 0.74
AKR1B1 P15121 1/20 0.74
TSHR P16473 1/20 0.74
PTGS2 P35354 1/20 0.74
TLR4 O00206 1/20 0.71
LMNA P02545 1/20 0.71
TP53 P04637 1/20 0.71
GLA P06280 1/20 0.71
HMGB1 P09429 1/20 0.71
MAPT P10636 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aminopterin SCHEMBL9514067 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL20769794 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL1626034 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL29443569 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL8161477 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL29398079 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL23581239 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL5024596 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL2504074 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL2387187 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 86842 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
CN-116903624-B Polymorphs of aminopterin and salts thereof PTC medical MP Co. (US) 2026-05-26 CN claimed
EP-4743490-A1 HUMANIZED ANTI-CD7 ANTIBODY Christian-Albrechts-Universität zu Kiel (DE) 2026-05-20 EP claimed
US-12630593-B2 Method of killing leukemia cells by administration of recombinant'Y3 proteins UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-19 US claimed
WO-2026099502-A1 NOVEL DRUG CONJUGATES FOR TESTING CELLULAR DRUG UPTAKE Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2026-05-15 WO claimed
US-20260130855-A1 GAMMA POLYGLUTAMATED ANTIFOLATES AND USES THEREOF L E A F HOLDINGS GROUP LLC (US) 2026-05-14 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
EP-4729063-A2 TREATMENT OF CANCER USING COENZYME Q10 COMBINATION THERAPIES BPGbio, Inc. (US) 2026-04-22 EP claimed
US-20260091124-A1 CLICK-TO-RELEASE ON PROTEINS AND PEPTIDES VALANX BIOTECH GMBH (AT) 2026-04-02 US claimed
US-20260085061-A1 PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS SITRYX THERAPEUTICS LIMITED (GB) 2026-03-26 US claimed
EP-0118917-A2 Method for production of biologically active substances Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1984-09-19 EP claimed
EP-0118915-A2 Human cultured cell line OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-09-19 EP claimed
EP-0110955-A1 BRAIN-SPECIFIC DRUG DELIVERY. UNIV FLORIDA (US) 1984-06-20 EP claimed
EP-0096839-A1 Method for producing human antibody Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1983-12-28 EP claimed
WO-1983003968-A1 BRAIN-SPECIFIC DRUG DELIVERY UNIVERSITY OF FLORIDA (US) 1983-11-24 WO claimed
US-4411993-A ANTITUMOR AND -CARCINOGENIC AGENTS IMMUNEX CORPORATION 1983-10-25 US claimed
US-4407945-A Constitutive production of interleukin 2 by a T cell hybridoma IMMUNEX CORPORATION (US) 1983-10-04 US claimed
EP-0027657-B1 PROCESS FOR PRODUCING ANTIBODIES TO HEPATITIS VIRUS AND CELL LINES THEREFOR THE MASSACHUSETTS GENERAL HOSPITAL (US) 1983-09-28 EP claimed
EP-0075880-A2 Pyrido (2,3-d) pyrimidines Southern Research Institute (US) 1983-04-06 EP claimed
US-3981983-A Rapid, radiochemical-ligand binding assay for methotrexate CASE WESTERN RESERVE UNIVERSITY (US) 1976-09-21 US claimed