Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 9/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | TYMS | P04818 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | TLR4 | O00206 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminopterin SCHEMBL2504074 | 1.00 | DHFR (0.75) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL29443569 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL29398079 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL20769794 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL1626034 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL8161477 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL8887 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL9514067 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL23581239 | 0.98 | DHFR (0.75) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL2387187 | 0.98 | DHFR (0.75) | DHFRKDM4EMEN1ALDH1A1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9867828-B2 | Aminopterin dosage forms | AMINOPTERIN LLC (US) | 2018-01-16 | — | — | US | claimed |
| US-9168256-B2 | Stable solid dosage forms of aminopterin | AMINOPTERIN LLC (US) | 2015-10-27 | — | — | US | claimed |
| US-20080058338-A1 | Stable Solid Dosage Forms of Aminopterin | SYNTRIX BIOSYSTEMS, INC. (US) | 2008-03-06 | — | — | US | claimed |
| US-12350271-B2 | Gamma polyglutamated aminopterin and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2025-07-08 | — | — | US | disclosed |
| US-20250213578-A1 | ALPHA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2025-07-03 | — | — | US | disclosed |
| US-12310966-B2 | Alpha polyglutamated aminopterin and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2025-05-27 | — | — | US | disclosed |
| US-20210213019-A1 | GAMMA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-07-15 | — | — | US | disclosed |
| US-20210052592-A1 | ALPHA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-02-25 | — | — | US | disclosed |
| EP-3752158-A1 | GAMMA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F Holdings Group LLC (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3749320-A1 | ALPHA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F Holdings Group LLC (US) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019160732-A1 | GAMMA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-22 | — | — | WO | disclosed |
| WO-2019157123-A1 | ALPHA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| US-9168256-B2 | Stable solid dosage forms of aminopterin | AMINOPTERIN LLC (US) | 2015-10-27 | — | — | US | disclosed |
| US-20080058338-A1 | Stable Solid Dosage Forms of Aminopterin | SYNTRIX BIOSYSTEMS, INC. (US) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250213578-A1 | ALPHA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | FOLH1, QPCT, SGTA | DHFR 134/4885KDM4E 3931/4885MEN1 1269/4885 |
| US-20210052592-A1 | ALPHA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | FOLH1, QPCT, SGTA | DHFR 134/4885KDM4E 3931/4885MEN1 1269/4885 |
| US-20210213019-A1 | GAMMA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | QPCT, SGTA, IFNG | DHFR 145/4885KDM4E 4096/4885MEN1 1776/4885 |
| US-12310966-B2 | Alpha polyglutamated aminopterin and uses thereof | FOLH1, QPCT, SGTA | DHFR 134/4885KDM4E 3931/4885MEN1 1269/4885 |
| US-12350271-B2 | Gamma polyglutamated aminopterin and uses thereof | QPCT, SGTA, IFNG | DHFR 145/4885KDM4E 4096/4885MEN1 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.