Aminopterin

Aminopterin

SCHEMBL29443569

Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 9/20 0.76
KDM4E B2RXH2 2/20 0.74
MEN1 O00255 2/20 0.74
ALDH1A1 P00352 2/20 0.74
TYMS P04818 2/20 0.74
POLB P06746 2/20 0.74
HPGD P15428 2/20 0.74
KMT2A Q03164 2/20 0.74
HSD17B10 Q99714 2/20 0.74
TDP1 Q9NUW8 2/20 0.74
GAA P10253 1/20 0.74
AKR1B1 P15121 1/20 0.74
TSHR P16473 1/20 0.74
PTGS2 P35354 1/20 0.74
TLR4 O00206 1/20 0.71
LMNA P02545 1/20 0.71
TP53 P04637 1/20 0.71
GLA P06280 1/20 0.71
HMGB1 P09429 1/20 0.71
MAPT P10636 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aminopterin SCHEMBL9514067 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL20769794 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL1626034 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL8887 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL8161477 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL29398079 1.00 DHFR (0.76) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL23581239 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL5024596 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL2504074 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS
Aminopterin SCHEMBL2387187 0.99 DHFR (0.75) DHFRKDM4EMEN1ALDH1A1TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119942708-A Intelligent monitoring system based on intelligent industrial park 苏州烁永信息科技有限公司 2025-05-06 CN claimed
CN-118890013-A Multimode programmable gain amplifier suitable for high-precision analog front end 电子科技大学 2024-11-01 CN claimed
CN-116830168-A Dynamic vision sensing system with static capture mode 香港应用科技研究院有限公司 2023-09-29 CN claimed
EP-4090685-A1 ANTI-GAL3 ANTIBODIES AND METHODS OF USE TrueBinding, Inc. (US) 2022-11-23 EP claimed
CN-114231042-B Graft copolymer, medicine-carrying assembly thereof and preparation method 北京化工大学 2022-08-30 CN claimed
CN-114685585-A Nucleotide sequence, double-stranded oligonucleotide, pharmaceutical composition and conjugate, and preparation method and application thereof 苏州瑞博生物技术股份有限公司 2022-07-01 CN claimed
CN-114231042-A Graft copolymer, medicine-carrying assembly thereof and preparation method 北京化工大学 2022-03-25 CN claimed
US-12624354-B2 Methods and compositions for prime editing nucleotide sequences THE BROAD INSTITUTE, INC. (US) 2026-05-12 US disclosed
US-12624353-B2 Methods and compositions for prime editing nucleotide sequences THE BROAD INSTITUTE, INC. (US) 2026-05-12 US disclosed
US-12570972-B2 Methods and compositions for prime editing nucleotide sequences THE BROAD INSTITUTE, INC. (US) 2026-03-10 US disclosed
US-12565660-B2 Immunomodulating transgenic plants and related methods AGRIVIDA, INC. (US) 2026-03-03 US disclosed
US-20260055281-A1 ANTIBACTERIAL WATER-BASED PAINT THAT IS ACTIVATED BY METALLIC NANOPARTICLES FLUOINK NANOTECHNOLOGIES (TN) 2026-02-26 US disclosed
CN-118890013-B Multimode programmable gain amplifier suitable for high-precision analog front end 电子科技大学 2026-01-06 CN disclosed
CN-114746105-A IL-15 compositions and methods of use thereof 普罗维瓦疗法香港有限公司 2022-07-12 CN disclosed
CN-114685585-A Nucleotide sequence, double-stranded oligonucleotide, pharmaceutical composition and conjugate, and preparation method and application thereof 苏州瑞博生物技术股份有限公司 2022-07-01 CN disclosed
CN-114664429-A Method for detecting benign and malignant breast tumor and application thereof 上海爱谱蒂康生物科技有限公司 2022-06-24 CN disclosed
WO-2022106365-A1 TETRAPEPTIDES, COMPOSITIONS COMPRISING THEM, AND THEIR COSMETIC USE SEDERMA (FR) 2022-05-27 WO disclosed
CN-109504661-B Antigen-specific T lymphocyte hybridoma and preparation method and application thereof 上海昀怡健康科技发展有限公司 2022-04-26 CN disclosed
CN-114231042-A Graft copolymer, medicine-carrying assembly thereof and preparation method 北京化工大学 2022-03-25 CN disclosed
CN-111315008-B Communication time sequence setting method for control station and mobile station 东南大学 2022-03-08 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12624354-B2 Methods and compositions for prime editing nucleotide sequences POLM, FEN1, SSU72 DHFR 591/4885KDM4E 3044/4885MEN1 4385/4885
US-20260055281-A1 ANTIBACTERIAL WATER-BASED PAINT THAT IS ACTIVATED BY METALLIC NANOPARTICLES CD44, CD47, CD4 DHFR 3612/4885KDM4E 3115/4885MEN1 4203/4885
US-12624353-B2 Methods and compositions for prime editing nucleotide sequences RNGTT, FEN1, POLB DHFR 456/4885KDM4E 2634/4885MEN1 4350/4885
US-12565660-B2 Immunomodulating transgenic plants and related methods SET, IL2, IL2RA DHFR 2904/4885KDM4E 2560/4885MEN1 4594/4885
US-12570972-B2 Methods and compositions for prime editing nucleotide sequences RNGTT, FEN1, POLM DHFR 282/4885KDM4E 3239/4885MEN1 4249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.