Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 9/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | TYMS | P04818 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | TLR4 | O00206 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminopterin SCHEMBL29398079 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL20769794 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL8887 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL1626034 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL8161477 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL29443569 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL9514067 | 0.99 | DHFR (0.76) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL23581239 | 0.98 | DHFR (0.75) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL5024596 | 0.98 | DHFR (0.75) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Aminopterin SCHEMBL2504074 | 0.98 | DHFR (0.75) | DHFRKDM4EMEN1ALDH1A1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023818-B2 | Pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use | GLYCON LLC (US) | 2015-05-05 | — | — | US | disclosed |
| US-20140057869-A9 | Novel Pharmaceutical Agents Containing Carbohydrate Moieties And Methods Of Their Preparation And Use | IMI INTERNATIONAL MEDICAL INNOVATIONS, INC. | 2014-02-27 | — | — | US | disclosed |
| US-20110237544-A1 | Novel Pharmaceutical Agents Containing Carbohydrate Moieties And Methods Of Their Preparation And Use | CHRISTIAN SAMUEL T | 2011-09-29 | — | — | US | disclosed |
| US-20060189547-A1 | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use | CHRISTIAN SAMUEL T | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189547-A1 | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use | CSGALNACT1, DDOST, STT3B | DHFR 867/4885KDM4E 3933/4885MEN1 1674/4885 |
| US-20110237544-A1 | Novel Pharmaceutical Agents Containing Carbohydrate Moieties And Methods Of Their Preparation And Use | CSGALNACT1, DDOST, STT3B | DHFR 867/4885KDM4E 3933/4885MEN1 1674/4885 |
| US-20140057869-A9 | Novel Pharmaceutical Agents Containing Carbohydrate Moieties And Methods Of Their Preparation And Use | CSGALNACT1, DDOST, STT3B | DHFR 867/4885KDM4E 3933/4885MEN1 1674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.