Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687878 | 0.84 | TSHR (0.79) | MEN1KMT2ATSHR | |
| SCHEMBL8934937 | 0.81 | TSHR (0.63) | MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL15768278 | 0.80 | MEN1 (0.57) | MEN1KMT2ATSHRMAPTALDH1A1 | |
| SCHEMBL3931936 | 0.80 | RAB9A (0.65) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL3649965 | 0.79 | TSHR (0.61) | MEN1KMT2ATSHRMAPTALDH1A1 | |
| SCHEMBL7088596 | 0.79 | NPC1 (0.66) | TSHRMAPTNPC1RAB9APOLB | |
| SCHEMBL8660366 | 0.79 | NPC1 (0.83) | MEN1KMT2ATSHRMAPTALDH1A1 | |
| SCHEMBL6263820 | 0.79 | NPC1 (0.83) | MEN1KMT2ATSHRMAPTALDH1A1 | |
| SCHEMBL8886838 | 0.79 | MEN1 (0.69) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL9551946 | 0.79 | MAPT (0.70) | MEN1KMT2ATSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602277-A | Substituted benzene derivatives useful as neuraminidase inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| WO-1996030329-A1 | SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INCORPORATED (US) | 1996-10-03 | — | — | WO | disclosed |