Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.54 |
| ▸ | HTR1B | P28222 | 10/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887664 | 0.78 | HTR1D (0.66) | HTR1DHTR1BDRD2DRD3CYP1A2 | |
| SCHEMBL7437400 | 0.78 | FYN (0.43) | HTR1DHTR1BDRD2DRD3HTR1A | |
| SCHEMBL8132500 | 0.71 | DRD2 (0.54) | HTR1DHTR1BDRD2DRD3HTR1A | |
| SCHEMBL10972719 | 0.71 | HTR1D (0.57) | HTR1DHTR1BDRD2DRD3HTR1A | |
| SCHEMBL8886408 | 0.70 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL7439769 | 0.70 | FYN (0.56) | HTR1DHTR1BDRD2DRD3HTR1A | |
| SCHEMBL8317195 | 0.70 | HTR1D (0.59) | HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL8886184 | 0.69 | HTR1D (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL9186743 | 0.68 | DRD2 (0.80) | HTR1DHTR1BDRD2DRD3CYP1A2 | |
| SCHEMBL8887262 | 0.67 | HTR1D (1.00) | HTR1DHTR1BDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |