Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylguanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylguanidine SCHEMBL1950328 | 0.98 | TP53 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL300643 | 0.98 | TP53 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL256023 | 0.91 | ALDH1A1 (0.58) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL11154590 | 0.89 | HSD17B10 (0.59) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL28414520 | 0.89 | HSD17B10 (0.52) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL29249611 | 0.89 | ALDH1A1 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL11092906 | 0.89 | ALDH1A1 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL4027020 | 0.89 | ALDH1A1 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL28765733 | 0.85 | HSD17B10 (0.48) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL10882671 | 0.84 | MAPT (0.52) | TP53TSHREPHX1EPHX2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602277-A | Substituted benzene derivatives useful as neuraminidase inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| WO-1996030329-A1 | SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INCORPORATED (US) | 1996-10-03 | — | — | WO | disclosed |