Sugi Predict

Sugi Predict / Compounds / SCHEMBL8888

SCHEMBL8888

SCHEMBL8888

COc1ncc(C)c(OC)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ QPCT Q16769 1/20 0.40
▸ QPCTL Q9NXS2 1/20 0.40
▸ CYP1A2 P05177 7/20 0.39
▸ RXRA P19793 1/20 0.37
▸ GRIN1 Q05586 1/20 0.37
▸ GRIN2B Q13224 1/20 0.37
▸ CRHR1 P34998 1/20 0.36
▸ METAP2 P50579 1/20 0.36
▸ PLAU P00749 1/20 0.35
▸ NUDT1 P36639 1/20 0.35
▸ PIK3CA P42336 2/20 0.35
▸ PIK3CD O00329 1/20 0.35
▸ ABL1 P00519 1/20 0.35
▸ EGFR P00533 1/20 0.35
▸ HCK P08631 1/20 0.35
▸ SRC P12931 1/20 0.35
▸ PIK3CB P42338 1/20 0.35
▸ MTOR P42345 1/20 0.35
▸ PIK3CG P48736 1/20 0.35
▸ EPHB4 P54760 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26794294 0.85 RXRA (0.35) QPCTQPCTLRXRAGRIN1GRIN2B
SCHEMBL14066720 0.82 AURKA (0.39) QPCTQPCTLCYP1A2RXRAGRIN1
SCHEMBL12051547 0.79 CYP1A2 (0.47) CYP1A2RXRAGRIN1GRIN2BPIK3CA
SCHEMBL9918974 0.79 LMNA (0.38) RXRAGRIN1GRIN2BNUDT1ALDH1A1
SCHEMBL3816071 0.77 KMT2A (0.52) QPCTQPCTLCYP1A2CRHR1METAP2
SCHEMBL23994815 0.76 QPCT (0.39) QPCTQPCTLCYP1A2CRHR1METAP2
SCHEMBL1494102 0.76 QPCT (0.39) QPCTQPCTLCYP1A2CRHR1METAP2
Hydrochloric Acid SCHEMBL6635486 0.76 KMT2A (0.50) QPCTQPCTLCYP1A2CRHR1METAP2
SCHEMBL322170 0.76 GAA (0.53) QPCTQPCTLCYP1A2CRHR1METAP2
SCHEMBL2511301 0.76 QPCT (0.39) QPCTQPCTLCYP1A2CRHR1METAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-11771738-B2 Endoparasitic depsipeptides ZOETIS SERVICES LLC (US) 2023-10-03 — — US disclosed
US-11771738-B2 Endoparasitic depsipeptides ZOETIS SERVICES LLC (US) 2023-10-03 — — US disclosed
US-20230039553-A1 CD73 COMPOUNDS GILEAD SCIENCES, INC. 2023-02-09 — — US disclosed
US-20210401840-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2021-12-30 — — US disclosed
EP-3885343-A1 INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF Dana-Farber Cancer Institute, Inc. (US) 2021-09-29 — — EP disclosed
US-11020399-B2 Intermediates useful in the synthesis of compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2021-06-01 — — US disclosed
WO-2021062168-A1 SYNTHETIC SPHINGOLIPID INSPIRED MOLECULES WITH HETEROAROMATIC APPENDAGES, METHODS OF THEIR SYNTHESIS AND METHODS OF TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-04-01 — — WO disclosed
US-20200239427-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2020-07-30 — — US disclosed
US-20070140960-A1 METHODS FOR IMAGING SOLUBLE A-BETA GENERAL ELECTRIC COMPANY (US) 2007-06-21 — — US disclosed
US-20070140960-A1 METHODS FOR IMAGING SOLUBLE A-BETA GENERAL ELECTRIC COMPANY (US) 2007-06-21 — — US disclosed
US-7223778-B2 5-substituted-2-arylpyridines NEUROGEN CORPORATION (US) 2007-05-29 — — US disclosed
US-7202250-B2 Substituted arylpyrazines NEUROGEN CORPORATION (US) 2007-04-10 — — US disclosed
US-20070078135-A1 Substituted heteroaryl CB1 antagonists NEUROGEN CORPORATION (US) 2007-04-05 — — US disclosed
US-7018786-B2 Toning agents for use in thermographic recording materials AGFA GEVAERT (BE) 2006-03-28 — — US disclosed
US-20040152027-A1 Toning agents for use in thermographic recording materials AGFA-GEVAERT (BE) 2004-08-05 — — US disclosed
EP-1435298-A2 Toning agents for use in thermographic and photothermographic recording materials Agfa-Gevaert (BE) 2004-07-07 — — EP disclosed
CN-1511140-A Oxime ether compound and agricultural or horticultural bactericide �ձ�������ʽ���� 2004-07-07 — — CN disclosed
CN-1047220-A PAN GRANULATION DU PONT (US) 1990-11-28 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230039553-A1 CD73 COMPOUNDS ENTPD5, ENTPD1, NT5E QPCT 2128/4885QPCTL 4030/4885CYP1A2 3166/4885
US-20210401840-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB QPCT 3177/4885QPCTL 3820/4885CYP1A2 4618/4885
US-11020399-B2 Intermediates useful in the synthesis of compounds as modulators of protein kinases MAP4K2, MAP3K20, MAP3K1 QPCT 1634/4885QPCTL 3090/4885CYP1A2 1215/4885
US-20070140960-A1 METHODS FOR IMAGING SOLUBLE A-BETA APBA1, APP, FABP7 QPCT 1867/4885QPCTL 2356/4885CYP1A2 4693/4885
US-11771738-B2 Endoparasitic depsipeptides VIP, PREP, VIPR1 QPCT 453/4885QPCTL 564/4885CYP1A2 1888/4885
US-20070078135-A1 Substituted heteroaryl CB1 antagonists CNR1, CNR2, OPRL1 QPCT 1691/4885QPCTL 2548/4885CYP1A2 808/4885
US-20200239427-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB QPCT 3658/4885QPCTL 4129/4885CYP1A2 4696/4885
US-11858907-B2 Kinase modulators RPS6KA1, RPS6KA2, PRKAR2A QPCT 2628/4885QPCTL 3846/4885CYP1A2 2024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.