Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28134429 | 0.73 | MTNR1A (0.49) | NPSR1SMN1; SMN2TSHRMAPT | |
| SCHEMBL3730600 | 0.71 | GAA (0.52) | GAAALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL6615213 | 0.70 | TAS1R3 (0.62) | GAAALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL4387054 | 0.70 | HPGD (0.41) | ALDH1A1TSHR | |
| SCHEMBL7688624 | 0.69 | GAA (0.53) | GAAALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL4822121 | 0.68 | CYP1A2 (0.41) | NPSR1MEN1KMT2ATP53TSHR | |
| SCHEMBL15758573 | 0.68 | HPGD (0.40) | TSHR | |
| SCHEMBL6711198 | 0.68 | GAA (0.76) | GAAALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL27581667 | 0.67 | MAOB (0.42) | TSHRMAPT | |
| SCHEMBL975666 | 0.67 | CHRNB2 (0.67) | GAAALDH1A1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700818-A | Dihydrobenzofuranyl-biphenyl carboxamides having 5HT1D antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-23 | — | — | US | disclosed |
| US-5700818-A | Dihydrobenzofuranyl-biphenyl carboxamides having 5HT1D antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-23 | — | — | US | disclosed |