Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLRE1B | Q9H816 | 3/20 | 0.57 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887303 | 0.92 | DCLRE1B (0.58) | DCLRE1BSGK1CAMKK2PDGFRBPDGFRA | |
| SCHEMBL8887805 | 0.84 | CAMKK2 (0.56) | DCLRE1BSGK1CAMKK2GRIN2BMAP4K4 | |
| Hydrochloric Acid SCHEMBL8502250 | 0.81 | HCRTR1 (0.46) | DCLRE1BPDGFRBPDGFRADHODHMAP4K4 | |
| SCHEMBL8502256 | 0.80 | CSNK2A2 (0.54) | DCLRE1BPDGFRBPDGFRAGRIN2BMAP4K4 | |
| Hydrochloric Acid SCHEMBL8891443 | 0.80 | PDGFRB (0.53) | SGK1CAMKK2PDGFRBPDGFRADHODH | |
| SCHEMBL8500962 | 0.76 | PDGFRB (0.62) | PDGFRBPDGFRAMAOB | |
| SCHEMBL8503211 | 0.74 | CDK8 (0.58) | PDGFRBPDGFRAGRIN2BMAP4K4CSNK1G2 | |
| SCHEMBL8503239 | 0.73 | DHODH (0.49) | DCLRE1BPDGFRBPDGFRADHODHMAP4K4 | |
| SCHEMBL8499693 | 0.73 | PDGFRB (0.52) | DCLRE1BPDGFRBPDGFRAGRIN2BMAP4K4 | |
| SCHEMBL9518777 | 0.73 | DCLRE1B (0.55) | DCLRE1BSGK1CAMKK2DCLRE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |