Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLRE1B | Q9H816 | 3/20 | 0.58 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889501 | 0.92 | DCLRE1B (0.57) | DCLRE1BSGK1CAMKK2PDGFRBPDGFRA | |
| SCHEMBL8887805 | 0.84 | CAMKK2 (0.56) | DCLRE1BSGK1CAMKK2GRIN2BMAP4K4 | |
| SCHEMBL8499693 | 0.81 | PDGFRB (0.52) | DCLRE1BPDGFRBPDGFRAGRIN2BMAP4K4 | |
| SCHEMBL8503239 | 0.81 | DHODH (0.49) | DCLRE1BPDGFRBPDGFRADHODHMAP4K4 | |
| SCHEMBL8889438 | 0.80 | PDGFRB (0.55) | PDGFRBPDGFRADHODHMAP4K4CSNK1G2 | |
| SCHEMBL8502253 | 0.76 | PDGFRB (0.64) | PDGFRBPDGFRAGRIN2BMAP4K4CSNK1G2 | |
| SCHEMBL8499648 | 0.74 | PDE3B (0.55) | PDGFRBPDGFRA | |
| SCHEMBL8501205 | 0.74 | PDGFRB (0.51) | PDGFRBPDGFRADHODHGRIN2BMAP4K4 | |
| SCHEMBL8502612 | 0.74 | CDK8 (0.58) | PDGFRBPDGFRAGRIN2BMAP4K4CSNK1G2 | |
| SCHEMBL8501202 | 0.74 | FFAR1 (0.51) | PDGFRBPDGFRAEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |