Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13715378 | 0.83 | BRPF1 (0.69) | LMNAALDH1A1HTTBRPF1MEN1 | |
| SCHEMBL16453789 | 0.83 | ALDH1A1 (0.80) | LMNAALDH1A1HTTMEN1KMT2A | |
| SCHEMBL3762044 | 0.82 | KDM4E (0.50) | LMNAALDH1A1HTTBRPF1DYRK1A | |
| SCHEMBL597397 | 0.81 | CLEC4M (0.47) | LMNAALDH1A1HTTBRPF1MEN1 | |
| SCHEMBL4232413 | 0.79 | CLEC4M (0.50) | LMNAALDH1A1HTTBRPF1MEN1 | |
| SCHEMBL17113293 | 0.78 | NR4A2 (0.70) | LMNAALDH1A1HTTBRPF1MAPT | |
| SCHEMBL8891630 | 0.78 | ALDH1A1 (0.52) | LMNAALDH1A1HTTBRPF1MEN1 | |
| SCHEMBL5269845 | 0.78 | DYRK1A (0.46) | LMNAALDH1A1HTTBRPF1DYRK1A | |
| SCHEMBL14631629 | 0.76 | DYRK1A (0.45) | LMNAALDH1A1HTTBRPF1DYRK1A | |
| SCHEMBL6029970 | 0.76 | NR4A2 (0.51) | LMNAALDH1A1HTTBRPF1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997006144-A1 | 2-CARBOCYCLIC AND 2-HETEROCYCLIC QUINOLINE-4-CARBOXYLIC ACIDS AND SALTS THEREOF USEFUL AS IMMUNOSUPPRESSIVE AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-02-20 | — | — | WO | disclosed |
| US-5578609-A | INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE, ANTITUMOR, TREATMENT OF ORGAN REJECTION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| US-5523408-A | USED FOR TREATMENT OR PREVENTION OF ORGAN TRANSPLANT REJECTION, GRAFT VERSUS HOST DISEASE, CHRONIC INFLAMMATORY DISEASES LIKE PSORIASIS, RHEUMATOID ARTHRITIS IN MAMMAL | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-06-04 | — | — | US | disclosed |