Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | DNA2 | P51530 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762044 | 0.88 | KDM4E (0.50) | DYRK1ABRPF1NR4A2ALDH1A1LMNA | |
| SCHEMBL14631629 | 0.85 | DYRK1A (0.45) | DYRK1ABRPF1NR4A2ALDH1A1LMNA | |
| SCHEMBL6029970 | 0.81 | NR4A2 (0.51) | DYRK1ABRPF1NR4A2ALDH1A1LMNA | |
| SCHEMBL1559436 | 0.80 | RAB9A (0.49) | BRPF1 | |
| SCHEMBL27599870 | 0.80 | BRPF1 (0.71) | BRPF1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL4232413 | 0.78 | CLEC4M (0.50) | BRPF1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL5943223 | 0.78 | ALDH1A1 (0.68) | BRPF1ALDH1A1LMNAHTTHPGD | |
| SCHEMBL8889718 | 0.78 | LMNA (0.56) | DYRK1ABRPF1NR4A2ALDH1A1LMNA | |
| SCHEMBL17113293 | 0.78 | NR4A2 (0.70) | DYRK1ABRPF1NR4A2ALDH1A1LMNA | |
| SCHEMBL7838694 | 0.78 | PIM3 (0.58) | DYRK1ABRPF1NR4A2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852420-B1 | Indole compounds for treating respiratory disorders | ONO PHARMACEUTICAL CO (JP) | 2012-10-17 | — | — | EP | disclosed |
| EP-1852420-A1 | INDOLE COMPOUND AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-11-07 | — | — | EP | disclosed |