Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.54 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8897722 | 0.91 | SCN9A (0.54) | THRBSCN9AGSTP1EPHA2KDR | |
| SCHEMBL8890864 | 0.86 | THRB (0.51) | THRBSCN9AGSTP1EPHA2KDR | |
| SCHEMBL8899814 | 0.86 | SCN9A (0.50) | THRBSCN9AGSTP1EPHA2KDR | |
| SCHEMBL8892213 | 0.81 | MAPT (0.58) | THRBSCN9AGSTP1MAPTTP53 | |
| SCHEMBL8899857 | 0.81 | MAPT (0.58) | THRBSCN9AGSTP1MAPTTP53 | |
| SCHEMBL8890634 | 0.77 | PDE4D (0.60) | THRBGSTP1EPHA2KDREPHB4 | |
| SCHEMBL8898815 | 0.76 | TSHR (0.59) | THRBGSTP1EPHA2KDREPHB4 | |
| SCHEMBL8889796 | 0.74 | THRB (0.59) | THRBMAPTTP53TSHRMAPK1 | |
| SCHEMBL8891881 | 0.71 | MAPT (0.49) | THRBGSTP1EPHA2KDREPHB4 | |
| SCHEMBL8891883 | 0.71 | MAPT (0.49) | THRBGSTP1EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |