Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890694 | 0.81 | ALOX5 (0.68) | ALOX5FFAR1 | |
| SCHEMBL8554718 | 0.81 | ALOX5 (0.69) | ALOX5PARP10ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8890266 | 0.80 | ALOX5 (0.67) | ALOX5FFAR1 | |
| SCHEMBL7072590 | 0.78 | HCAR2 (0.49) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL5873410 | 0.78 | HCAR2 (0.49) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL10746742 | 0.78 | HCAR2 (0.49) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL8908490 | 0.78 | PARP10 (0.53) | ALOX5PARP10ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4013173 | 0.77 | PARP10 (0.62) | ALOX5PARP10ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7742884 | 0.76 | KDM4E (0.65) | ALOX5PARP10ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7742881 | 0.76 | KDM4E (0.65) | ALOX5PARP10ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012866-A1 | BIS-HETEROARYLYLMETHOXYPHENYLKETONE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | claimed |