Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 9/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899135 | 0.94 | TRIM58 (0.53) | NPY5RADRA2AVCPTRIM58POLB | |
| SCHEMBL8898697 | 0.90 | VCP (0.46) | NPY5RADRA2AVCPPOLBAPP | |
| SCHEMBL8901739 | 0.88 | TAAR1 (0.52) | VCPPOLBRAD52APPACHE | |
| SCHEMBL8898260 | 0.88 | VCP (0.50) | VCPAPPACHE | |
| SCHEMBL8890072 | 0.87 | POLB (0.51) | NPY5RADRA2AVCPTRIM58POLB | |
| SCHEMBL8888887 | 0.87 | TLR9 (0.51) | PDE5AACP1NPY5RADRA2ATLR9 | |
| SCHEMBL8898947 | 0.87 | TLR9 (0.51) | PDE5AACP1NPY5RADRA2ATLR9 | |
| SCHEMBL8898351 | 0.86 | VCP (0.48) | PDE5AVCPAPPACHE | |
| SCHEMBL8889919 | 0.86 | VCP (0.52) | VCP | |
| SCHEMBL8889077 | 0.85 | VCP (0.47) | VCPAPPACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | claimed |
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |