Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 2/20 | 0.51 |
| ▸ | VCP | P55072 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | PGK1 | P00558 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898260 | 0.92 | VCP (0.50) | VCPAPPACHE | |
| SCHEMBL8899135 | 0.88 | TRIM58 (0.53) | POLBRAD52VCPALDH1A1KMT2A | |
| SCHEMBL8898351 | 0.88 | VCP (0.48) | VCPAPPACHEKDM4EALDH1A1 | |
| SCHEMBL8890197 | 0.88 | PDE5A (0.48) | POLBRAD52VCPAPPACHE | |
| SCHEMBL8889919 | 0.87 | VCP (0.52) | VCP | |
| SCHEMBL8901747 | 0.87 | TAAR1 (0.56) | TAAR1HTTPOLBSMN1; SMN2RAD52 | |
| SCHEMBL8890072 | 0.86 | POLB (0.51) | POLBVCPGAA | |
| SCHEMBL8889077 | 0.86 | VCP (0.47) | VCPAPPACHEKMT2A | |
| SCHEMBL8898697 | 0.86 | VCP (0.46) | POLBVCPAPPACHE | |
| SCHEMBL8891157 | 0.86 | NPY5R (0.54) | VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |