Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 11/20 | 0.69 |
| ▸ | MAOB | P27338 | 11/20 | 0.69 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.54 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | TOP1 | P11387 | 1/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728150 | 0.82 | MAOB (1.00) | MAOAMAOBTOP1GSTP1 | |
| SCHEMBL9183428 | 0.80 | EDNRA (0.60) | MAOAMAOBPDGFRAFERLTK | |
| SCHEMBL27634033 | 0.79 | MAOA (1.00) | MAOAMAOBTOP1GSTP1 | |
| SCHEMBL26547707 | 0.77 | MAOB (0.55) | MAOAMAOBCREBBPTOP1 | |
| SCHEMBL7379163 | 0.77 | MAOA (1.00) | MAOAMAOBTOP1GSTP1 | |
| SCHEMBL20520341 | 0.76 | MAOA (0.79) | MAOAMAOBCREBBPTOP1GSTP1 | |
| SCHEMBL30536411 | 0.75 | CES1 (0.62) | PDGFRAFERLTKCDK8ACVR1 | |
| SCHEMBL9179367 | 0.74 | MAOB (0.47) | MAOAMAOBTNKS2CREBBP | |
| SCHEMBL6351678 | 0.74 | MAOA (0.62) | MAOAMAOBTNKS2CREBBPTOP1 | |
| SCHEMBL6351677 | 0.74 | MAOA (0.62) | MAOAMAOBTNKS2CREBBPTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000252-A1 | TRICYCLIC INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-01-03 | — | — | WO | disclosed |
| US-5420123-A | Dibenzodiazepine endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-05-30 | — | — | US | disclosed |