SCHEMBL8890595

SCHEMBL8890595

N#CCCCN1CCN(c2ncccn2)CC1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 7/20 0.52
HTR1A P08908 6/20 0.52
DRD2 P14416 6/20 0.52
HTR2A P28223 4/20 0.52
DRD1 P21728 3/20 0.52
DRD5 P21918 2/20 0.52
DRD4 P21917 1/20 0.49
HRH3 Q9Y5N1 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL313690 0.85 DRD2 (0.54) DRD3HTR1ADRD2HTR2ADRD1
SCHEMBL26108581 0.83 HTR1A (0.65) DRD3HTR1ADRD2HTR2ADRD1
SCHEMBL26492991 0.83 HTR1A (0.65) DRD3HTR1ADRD2HTR2ADRD1
SCHEMBL10814729 0.82 KCNH2 (0.64) DRD3HTR1ADRD2HTR2ADRD1
Hydrochloric Acid SCHEMBL26108377 0.81 DRD2 (0.63) DRD3HTR1ADRD2HTR2ADRD1
SCHEMBL1254644 0.80 HTR1A (0.57) DRD3HTR1ADRD2HTR2ADRD1
SCHEMBL7656340 0.80 CYP2D6 (0.59) DRD3HTR1ADRD2HTR2ADRD1
SCHEMBL1306779 0.80 MEN1 (0.50) HTR1A
SCHEMBL9286378 0.78 LMNA (0.59) DRD3HTR1ADRD2HTR2ADRD1
SCHEMBL9260064 0.78 HTR1A (0.60) DRD3HTR1ADRD2HTR2ADRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0115506-B1 ACID SALTS OF 1-(CYANOALKYL)-4-GUANYLPIPERAZINES AND METHODS FOR THEIR PREPARATION AND USE EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-02-15 EP claimed
EP-0115506-A4 ACID SALTS OF 1-(CYANOALKYL)-4-GUANYLPIPERAZINES AND METHODS FOR THEIR PREPARATION AND USE. EASTMAN KODAK CO (US) 1985-04-23 EP claimed
EP-0115506-A1 ACID SALTS OF 1-(CYANOALKYL)-4-GUANYLPIPERAZINES AND METHODS FOR THEIR PREPARATION AND USE. EASTMAN KODAK CO (US) 1984-08-15 EP claimed
WO-1984000752-A1 ACID SALTS OF 1-(CYANOALKYL)-4-GUANYLPIPERAZINES AND METHODS FOR THEIR PREPARATION AND USE EASTMAN KODAK CO (US) 1984-03-01 WO claimed
US-5594034-A ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL ELI LILLY AND COMPANY (US) 1997-01-14 US disclosed
US-5594025-A Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane ELI LILLY AND COMPANY (US) 1997-01-14 US disclosed
EP-0455510-B1 Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion LILLY CO ELI (US) 1996-11-27 EP disclosed
US-5576352-A Method of inhibiting gastric acid secretion with aryloxypropanolamines ELI LILLY AND COMPANY (US) 1996-11-19 US disclosed
US-5457120-A Antisecretory and antiserotonine agents ELI LILLY AND COMPANY (US) 1995-10-10 US disclosed
US-5340838-A Administering serotonin agonist to mammals ELI LILLY AND COMPANY (US) 1994-08-23 US disclosed
US-5258379-A ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS ELI LILLY AND COMPANY (US) 1993-11-02 US disclosed
US-5158956-A Administering serotonin receptor agonist ELI LILLY AND COMPANY (US) 1992-10-27 US disclosed
EP-0115506-A1 ACID SALTS OF 1-(CYANOALKYL)-4-GUANYLPIPERAZINES AND METHODS FOR THEIR PREPARATION AND USE. EASTMAN KODAK CO (US) 1984-08-15 EP disclosed
EP-0114864-A1 2-PYRIMIDYL ALKANESULFONATES AND METHODS FOR THEIR PREPARATION AND USE. EASTMAN KODAK CO (US) 1984-08-08 EP disclosed
EP-0109562-A1 Succinimide derivatives and their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-05-30 EP disclosed
WO-1984000753-A1 CYANOALKYLPIPERAZINES AND METHODS FOR THEIR PREPARATION AND USE EASTMAN KODAK CO (US) 1984-03-01 WO disclosed
WO-1984000751-A1 2-PYRIMIDYL ALKANESULFONATES AND METHODS FOR THEIR PREPARATION AND USE EASTMAN KODAK CO (US) 1984-03-01 WO disclosed
WO-1984000752-A1 ACID SALTS OF 1-(CYANOALKYL)-4-GUANYLPIPERAZINES AND METHODS FOR THEIR PREPARATION AND USE EASTMAN KODAK CO (US) 1984-03-01 WO disclosed
US-4423049-A TRANQUILIZERS MEAD JOHNSON & COMPANY (US) 1983-12-27 US disclosed
US-3976776-A Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones MEAD JOHNSON & COMPANY (US) 1976-08-24 US disclosed