Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.52 |
| ▸ | PDE4A | P27815 | 12/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890415 | 0.76 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8889523 | 0.72 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8888975 | 0.72 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8900612 | 0.72 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890618 | 0.72 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890076 | 0.72 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.71 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8889395 | 0.71 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8891012 | 0.70 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890145 | 0.70 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |