Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891690 | 0.90 | HTT (0.37) | HTTALDH1A1MAPTHPGDCA2 | |
| SCHEMBL8892315 | 0.89 | ABCC9 (0.33) | HTTALDH1A1MAPTABCC9ABCC8 | |
| SCHEMBL8890978 | 0.88 | ABCC9 (0.47) | ALDH1A1ABCC9ABCC8KCNJ11CNR1 | |
| SCHEMBL8893730 | 0.88 | HTT (0.34) | HTTALDH1A1MAPTHPGDCA2 | |
| SCHEMBL8892844 | 0.87 | ABCC9 (0.39) | HTTALDH1A1MAPTHPGDABCC9 | |
| SCHEMBL8891839 | 0.86 | ALDH1A1 (0.50) | HTTALDH1A1MAPTHPGDCA2 | |
| SCHEMBL8891698 | 0.85 | GAA (0.39) | HTTALDH1A1MAPTHPGDABCC9 | |
| SCHEMBL8892054 | 0.84 | HTT (0.37) | HTTALDH1A1MAPTHPGDCA2 | |
| SCHEMBL8891448 | 0.84 | KDM4E (0.42) | HTTALDH1A1MAPTHPGDCA2 | |
| SCHEMBL8894111 | 0.84 | HTT (0.37) | HTTALDH1A1MAPTHPGDCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607976-A | ANNTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |