Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891913 | 0.90 | KDM4E (0.43) | KDM4EOPRM1OPRD1TP53ALDH1A1 | |
| SCHEMBL8891410 | 0.89 | KDM4E (0.41) | KDM4EOPRM1OPRD1TP53ALDH1A1 | |
| SCHEMBL8891256 | 0.88 | KDM4E (0.34) | KDM4EOPRM1OPRD1TP53ALDH1A1 | |
| SCHEMBL8891815 | 0.88 | ABCC9 (0.48) | ALDH1A1RAB9AABCC9ABCC8KCNJ11 | |
| SCHEMBL8891687 | 0.86 | LMNA (0.43) | KDM4EALDH1A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8891839 | 0.85 | ALDH1A1 (0.50) | KDM4EALDH1A1KMT2AMEN1CA2 | |
| SCHEMBL8894254 | 0.85 | NPSR1 (0.44) | KDM4EALDH1A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8892002 | 0.84 | HTT (0.36) | KDM4EALDH1A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8890321 | 0.83 | LMNA (0.35) | ALDH1A1ABCC9ABCC8KCNJ11KMT2A | |
| SCHEMBL8890328 | 0.82 | L3MBTL1 (0.43) | TP53ALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607976-A | ANNTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |