SCHEMBL8892485

SCHEMBL8892485

CSc1ccc(C(=O)c2cnoc2C2CC2)c(Cc2cccc(Cl)c2)c1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.35
LMNA P02545 2/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
CCR2 P41597 2/20 0.33
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
MAPK1 P28482 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
HCRTR1 O43613 1/20 0.32
HCRTR2 O43614 1/20 0.32
EPHX2 P34913 1/20 0.32
SMYD3 Q9H7B4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8891772 0.90 KMT2A (0.35) MAPTLMNANPC1RAB9AKDM4E
SCHEMBL8891282 0.90 HPGD (0.36) MAPTNPC1RAB9AALDH1A1HPGD
SCHEMBL8891097 0.85 KMT2A (0.38) MAPTLMNANPC1RAB9ACCR2
SCHEMBL8889854 0.85 SMN1; SMN2 (0.34) MAPTLMNANPC1RAB9APDE3B
SCHEMBL8892594 0.84 MAPT (0.35) MAPTLMNANPC1ALDH1A1KMT2A
SCHEMBL8892121 0.84 TBXA2R (0.36) MAPTLMNANPC1RAB9APDE3B
SCHEMBL8890001 0.84 KDM4E (0.36) MAPTLMNANPC1RAB9APDE3B
SCHEMBL8494970 0.83 HPGD (0.35) RAB9AALDH1A1HPGDPOLBKMT2A
SCHEMBL8891694 0.82 CCR5 (0.35) MAPTKDM4EALDH1A1MAPK1PTGDR2
SCHEMBL8890902 0.82 RAB9A (0.39) MAPTNPC1RAB9AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997028136-A1 BENZOYLISOXAZOLES AND 2-CYANO-1,3-DIONE DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1997-08-07 WO disclosed