Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 6/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909816 | 0.95 | CTSD (0.39) | CTSSRENCTSLCTSBCTSK | |
| SCHEMBL7431468 | 0.92 | CTSS (0.40) | CTSSRENCTSLCTSBCTSK | |
| SCHEMBL8892626 | 0.91 | REN (0.39) | CTSSRENCTSKBACE1CASP3 | |
| SCHEMBL8893984 | 0.91 | REN (0.39) | CTSSRENBACE1CASP3CTSD | |
| SCHEMBL8893998 | 0.90 | CTSS (0.39) | CTSSRENCTSLCTSBCTSK | |
| SCHEMBL8908391 | 0.89 | REN (0.37) | CTSSRENCTSKBACE1CASP3 | |
| SCHEMBL7442606 | 0.89 | PSEN1 (0.40) | CTSSRENCTSKBACE1CASP3 | |
| SCHEMBL7435623 | 0.89 | PSEN1 (0.40) | CTSSRENCTSKBACE1CASP3 | |
| SCHEMBL8892225 | 0.88 | REN (0.40) | RENBACE1CASP3CTSDAPP | |
| SCHEMBL8892199 | 0.88 | REN (0.37) | RENCTSLBACE1CASP3CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643878-A | TREATMENT OF RETROVIRAL DISEASES LIKE AIDS | CIBA-GEIGY CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0618222-A2 | Dipeptid derivatives of 5-amino-4-hydroxy-hexanoic acid | CIBA-GEIGY AG (CH) | 1994-10-05 | — | — | EP | disclosed |