SCHEMBL8894491

SCHEMBL8894491

CCOP(=O)(CCOc1c[c]c(F)cc1C#N)OCC

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
PSEN1 P49768 1/20 0.31
PSEN2 P49810 1/20 0.31
APH1B Q8WW43 1/20 0.31
NCSTN Q92542 1/20 0.31
APH1A Q96BI3 1/20 0.31
PSENEN Q9NZ42 1/20 0.31
PPARD Q03181 1/20 0.30
AR P10275 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5842236 0.88 TSHR (0.32) ARTSHR
SCHEMBL7745264 0.72 NPC1 (0.44) ALDH1A1HPGDARTSHR
SCHEMBL5841619 0.72 NLRP3 (0.43) ALDH1A1HPGDARTSHR
SCHEMBL5844428 0.72 KDM4E (0.37) ALDH1A1HPGD
SCHEMBL5844399 0.71 ALOX5AP (0.32)
SCHEMBL5842676 0.71 XDH (0.41)
SCHEMBL6595259 0.69 AR (0.48) ALDH1A1HPGDARTSHR
SCHEMBL7039720 0.69 CYP11B1 (0.30)
SCHEMBL5843345 0.69 ALDH1A1 (0.44) ALDH1A1AR
SCHEMBL5844366 0.68 AR (0.33) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997026248-A1 SUBSTITUTED N-ARYL NITROGEN HETEROCYCLIC COMPOUNDS AND THEIR USE AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-07-24 WO disclosed