Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 3/20 | 0.44 |
| ▸ | CPA1 | P15085 | 2/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894053 | 0.85 | REN (0.47) | MMP2MMP7MMP9MMP12MMP13 | |
| SCHEMBL11026589 | 0.79 | KLK5 (0.53) | — | |
| SCHEMBL11023324 | 0.78 | MEN1 (0.48) | — | |
| SCHEMBL7421175 | 0.77 | LTA4H (0.54) | MMP2MMP7MMP9MMP12MMP13 | |
| SCHEMBL29519583 | 0.77 | LTA4H (0.64) | MMP2MMP7MMP9MMP12MMP13 | |
| SCHEMBL27517670 | 0.77 | LTA4H (0.64) | MMP2MMP7MMP9MMP12MMP13 | |
| SCHEMBL28860411 | 0.77 | LTA4H (0.64) | MMP2MMP7MMP9MMP12MMP13 | |
| SCHEMBL2185269 | 0.77 | LTA4H (0.64) | MMP2MMP7MMP9MMP12MMP13 | |
| SCHEMBL1864709 | 0.77 | LTA4H (0.64) | MMP2MMP7MMP9MMP12MMP13 | |
| Water SCHEMBL29655482 | 0.76 | LTA4H (0.62) | MMP2MMP7MMP9MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | claimed |
| US-5688770-A | RENIN INHIBITOR AND BETA ADRENERGIC BLOCKING AGENT | SCHERING CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| US-5352666-A | Using a renin inhibitor | SCHERING CORPORATION (US) | 1994-10-04 | — | — | US | disclosed |
| US-4906613-A | Antiglaucoma compositions and methods | SCHERING CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0246381-A1 | Renin inhibitors and methods for using same | SCHERING CORPORATION (US) | 1987-11-25 | — | — | EP | disclosed |
| EP-0077029-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0077029-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | disclosed |