Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | IL1RN | P18510 | 5/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 3/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894053 | 0.94 | REN (0.47) | RENPSMB5CTSD | |
| SCHEMBL11026589 | 0.85 | KLK5 (0.53) | RENCTSD | |
| SCHEMBL8894644 | 0.78 | MMP2 (0.48) | — | |
| SCHEMBL11025954 | 0.77 | REN (0.67) | MEN1ALDH1A1LMNAKMT2AREN | |
| SCHEMBL11023793 | 0.73 | CTSD (0.62) | RENCTSD | |
| SCHEMBL10744547 | 0.73 | ALDH1A1 (0.67) | MEN1ALDH1A1LMNAKMT2ABIRC2 | |
| SCHEMBL8893254 | 0.70 | REN (0.67) | RENCTSD | |
| Bestatin Methyl Ester SCHEMBL9574604 | 0.70 | ANPEP (0.61) | ALDH1A1IL1RNERAP2ERAP1BIRC2 | |
| SCHEMBL30906720 | 0.70 | IL1RN (0.63) | ALDH1A1IL1RNERAP2ERAP1BIRC2 | |
| Bestatin Methyl Ester SCHEMBL15261304 | 0.70 | ANPEP (0.61) | ALDH1A1IL1RNERAP2ERAP1BIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077029-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0077029-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | disclosed |