Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | GPR34 | Q9UPC5 | 5/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11023324 | 0.94 | MEN1 (0.48) | RENPSMB5CTSD | |
| SCHEMBL8894644 | 0.85 | MMP2 (0.48) | ACEMMP2MMP7MMP9MMP12 | |
| SCHEMBL11026589 | 0.79 | KLK5 (0.53) | RENCTSD | |
| SCHEMBL8893254 | 0.76 | REN (0.67) | RENACECTSD | |
| SCHEMBL7970010 | 0.72 | GPR34 (0.73) | GPR34PSMB5 | |
| SCHEMBL10727176 | 0.72 | GPR34 (0.73) | GPR34PSMB5 | |
| SCHEMBL7296506 | 0.72 | GPR34 (0.73) | GPR34PSMB5 | |
| SCHEMBL8893459 | 0.72 | REN (0.61) | RENCTSD | |
| SCHEMBL10749186 | 0.72 | REN (0.61) | RENCTSD | |
| SCHEMBL5099551 | 0.71 | ALDH1A1 (0.74) | GPR34 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077029-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | claimed |
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | claimed |
| EP-0077029-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | claimed |
| US-5688770-A | RENIN INHIBITOR AND BETA ADRENERGIC BLOCKING AGENT | SCHERING CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| US-4906613-A | Antiglaucoma compositions and methods | SCHERING CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0246381-A1 | Renin inhibitors and methods for using same | SCHERING CORPORATION (US) | 1987-11-25 | — | — | EP | disclosed |
| EP-0243477-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| WO-1987002581-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-05-07 | — | — | WO | disclosed |
| EP-0077029-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0077029-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | disclosed |