Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 5/20 | 0.33 |
| ▸ | RXRB | P28702 | 4/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632757 | 0.89 | AKR1B1 (0.41) | AKR1B1RXRARXRBCYP26A1CYP26B1 | |
| SCHEMBL8892445 | 0.89 | MAPT (0.43) | MAPTNPC1RAB9AHSD17B1AKR1B1 | |
| SCHEMBL8563483 | 0.84 | RXRA (0.32) | RXRARXRBRXRG | |
| SCHEMBL7118667 | 0.78 | RXRA (0.33) | MAPTRXRARXRBCYP26A1CYP26B1 | |
| SCHEMBL8896716 | 0.77 | PDE4B (0.35) | TDP2 | |
| SCHEMBL8903275 | 0.72 | MAPT (0.41) | MAPTNPC1RAB9AHSD17B1AKR1B1 | |
| SCHEMBL17530495 | 0.71 | MAPT (0.42) | MAPTNPC1RAB9AHSD17B1AKR1B1 | |
| SCHEMBL12620671 | 0.70 | RXRA (0.42) | MAPTNPC1RAB9AAKR1B1RXRA | |
| SCHEMBL9626092 | 0.67 | RXRA (0.42) | MAPTNPC1RAB9AAKR1B1RXRA | |
| SCHEMBL6240160 | 0.67 | NPC1 (0.45) | MAPTNPC1RAB9AHSD17B1S100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |