Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 10/20 | 0.40 |
| ▸ | RARG | P13631 | 10/20 | 0.40 |
| ▸ | RARA | P10276 | 7/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 12/20 | 0.40 |
| ▸ | RXRB | P28702 | 10/20 | 0.40 |
| ▸ | RXRG | P48443 | 7/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895391 | 0.89 | MAPT (0.40) | AKR1B1RARBRARGCYP26A1CYP26B1 | |
| SCHEMBL8563483 | 0.84 | RXRA (0.32) | RXRARXRBRXRG | |
| SCHEMBL7118667 | 0.81 | RXRA (0.33) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL8892445 | 0.78 | MAPT (0.43) | AKR1B1RARBRARGCYP26A1CYP26B1 | |
| SCHEMBL8771776 | 0.76 | RARB (0.43) | AKR1B1RARBRARGRARACYP26A1 | |
| SCHEMBL1071564 | 0.71 | RXRA (0.46) | AKR1B1RARBRARGRARACYP26A1 | |
| SCHEMBL485022 | 0.69 | TDP2 (0.50) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL8771833 | 0.67 | RARB (0.52) | RARBRARGRARARXRA | |
| SCHEMBL13189905 | 0.67 | KDM1A (0.46) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL6292577 | 0.67 | RARB (0.51) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773594-A | TREATING SKIN DISORDERS, REDUCING SIDE EFFECTS OF OTHER RETINOIDS | ALLERGAN (US) | 1998-06-30 | — | — | US | disclosed |
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |