Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894440 | 0.86 | HMGCR (0.51) | HMGCRALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL9720549 | 0.86 | HMGCR (0.51) | HMGCRALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL28167755 | 0.86 | HMGCR (0.75) | HMGCRALDH1A1SMN1; SMN2LMNACYP3A4 | |
| SCHEMBL28860120 | 0.86 | HMGCR (0.45) | HMGCRALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL4764754 | 0.85 | HMGCR (0.72) | HMGCRALDH1A1GAACYP3A4 | |
| SCHEMBL24010659 | 0.85 | GAA (0.54) | HMGCRALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL30288429 | 0.85 | GAA (0.54) | HMGCRALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL23173889 | 0.84 | ALDH1A1 (0.45) | ALDH1A1GAASMN1; SMN2LMNAHTR4 | |
| SCHEMBL20507907 | 0.84 | HPGDS (0.47) | ALDH1A1GAASMN1; SMN2LMNAHTR4 | |
| SCHEMBL23173670 | 0.84 | ALDH1A1 (0.45) | ALDH1A1GAASMN1; SMN2LMNAHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656648-A | TREATMENT OF PATHOLOGIES NECESSITATING STIMULATION OF CHOLECYSTOKININ-A RECEPTORS BY TOTAL OR PARTIAL AGONIST EFFECT | SANOFI (FR) | 1997-08-12 | — | — | US | disclosed |
| EP-0611766-A1 | Polysubstituted 2-amido thiazoles derivatives, process for their preparation, pharmaceutical compositions and utilization for the preparation of a medicament | SANOFI (FR) | 1994-08-24 | — | — | EP | disclosed |