Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894440 | 0.87 | HMGCR (0.51) | HMGCRSMN1; SMN2KMT2AALDH1A1GAA | |
| SCHEMBL8895935 | 0.86 | HMGCR (0.54) | HMGCRSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL13284211 | 0.86 | HMGCR (0.68) | HMGCRSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL23174094 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL20507490 | 0.85 | HPGDS (0.45) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9720571 | 0.84 | HMGCR (0.56) | HMGCRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL28167755 | 0.83 | HMGCR (0.75) | HMGCRSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL30288429 | 0.82 | GAA (0.54) | HMGCRSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL24010659 | 0.82 | GAA (0.54) | HMGCRSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL16200306 | 0.81 | ALDH1A1 (0.47) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5103022-A | Reacting dl-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino -1-propanone with l-acetylphenylglycine to form corresponding diastereomeric salt, deposition, isolation of l-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5057535-A | Muscle relaxants | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1991-10-15 | — | — | US | disclosed |
| EP-0200942-A2 | New derivatives of an aminoketone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | disclosed |