Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NAT1 | P18440 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893765 | 0.86 | TNKS2 (0.36) | TNKS2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8532254 | 0.81 | CYP1A2 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2C9NAT1 | |
| SCHEMBL8532250 | 0.81 | CYP1A2 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2C9NAT1 | |
| SCHEMBL8957287 | 0.80 | CYP1A2 (0.50) | ALDH1A1CYP1A2CYP3A4CYP2C9NAT1 | |
| SCHEMBL9027978 | 0.80 | NAT1 (0.56) | NAT1MEN1KMT2A | |
| SCHEMBL8894717 | 0.80 | NAT1 (0.56) | NAT1MEN1KMT2A | |
| SCHEMBL9684891 | 0.79 | TNKS2 (0.39) | TNKS2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9684884 | 0.79 | TNKS2 (0.39) | TNKS2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8533654 | 0.76 | GAA (0.39) | ALDH1A1CYP1A2CYP3A4CYP2C9NAT1 | |
| SCHEMBL8895054 | 0.72 | PTGS2 (0.44) | ALDH1A1CYP1A2CYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| EP-0691129-A2 | Thiazolidone and pyrrolidinone compounds for inhibiting bone loss | ELI LILLY AND COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5158966-A | Aryl-substituted rhodanine derivatives | THE UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0500337-A1 | Composition containing aryl-substituted rhodanine derivatives for the treatment of type I diabetes | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-08-26 | — | — | EP | disclosed |
| EP-0391644-A2 | Aryl-substituted rhodanine derivatives | ELI LILLY AND COMPANY (US) | 1990-10-10 | — | — | EP | disclosed |