Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896458 | 0.99 | VCAM1 (0.49) | VCAM1SLC9A1ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8894967 | 0.93 | VCAM1 (0.51) | VCAM1SLC9A1ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL29825874 | 0.83 | ALDH1A1 (0.43) | VCAM1ALDH1A1SMN1; SMN2NPSR1KMT2A | |
| SCHEMBL22636985 | 0.81 | ALDH1A1 (0.48) | VCAM1ALDH1A1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL30153250 | 0.81 | ALDH1A1 (0.48) | VCAM1ALDH1A1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL18459668 | 0.80 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2ATMNPSR1KMT2A | |
| SCHEMBL8581253 | 0.80 | SLC9A1 (0.47) | VCAM1SLC9A1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1763095 | 0.80 | SLC9A1 (0.52) | SLC9A1KDM4EMAPTTHRB | |
| SCHEMBL17164563 | 0.79 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2ATMNPSR1KMT2A | |
| SCHEMBL3900393 | 0.79 | KDM4E (0.55) | ALDH1A1L3MBTL1SMN1; SMN2ATMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693672-A | 3,4,5-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-02 | — | — | US | disclosed |