SCHEMBL22636985

SCHEMBL22636985

COC(=O)c1ccc(C2CC2)c(S(=O)(=O)Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
SMN1; SMN2 Q16637 3/20 0.45
CYP1A2 P05177 1/20 0.45
TSHR P16473 1/20 0.45
CYP2C19 P33261 1/20 0.45
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
KDM4E B2RXH2 7/20 0.42
KMT2A Q03164 2/20 0.42
CHRNB2 P17787 1/20 0.42
CHRNA4 P43681 1/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
XDH P47989 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30153250 1.00 ALDH1A1 (0.48) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR
SCHEMBL8894967 0.87 VCAM1 (0.51) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR
SCHEMBL31401320 0.83 CDC25B (0.45) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL8896458 0.82 VCAM1 (0.49) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR
SCHEMBL8896076 0.81 VCAM1 (0.48) ALDH1A1L3MBTL1SMN1; SMN2KDM4EKMT2A
SCHEMBL15778276 0.79 SLC6A3 (0.53) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR
SCHEMBL16893324 0.78 ALDH1A1 (0.46) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR
SCHEMBL7818115 0.78 CHRNB2 (0.44) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR
SCHEMBL31587402 0.77 ALDH1A1 (0.50) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR
SCHEMBL669263 0.77 ALDH1A1 (0.50) ALDH1A1L3MBTL1SMN1; SMN2CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12485169-B2 Compounds Grey Wolf Therapeutics Limited (GB) 2025-12-02 US disclosed
US-12377084-B2 ERAP1 modulators Grey Wolf Therapeutics Limited (GB) 2025-08-05 US disclosed
US-20240376046-A1 PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS Grey Wolf Therapeutics Limited (GB) 2024-11-14 US disclosed
US-20240366595-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2024-11-07 US disclosed
US-12023333-B2 Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators Grey Wolf Therapeutics Limited (GB) 2024-07-02 US disclosed
EP-4376955-A1 PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS Grey Wolf Therapeutics Limited (GB) 2024-06-05 EP disclosed
CN-117881657-A Phenyl-sulfamoyl-benzoic acid derivatives as ERAP1 modulators 格雷沃尔夫治疗有限公司 2024-04-12 CN disclosed
US-20230064417-A1 COMPOUNDS Grey Wolf Therapeutics Limited (GB) 2023-03-02 US disclosed
WO-2023007188-A1 PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS Grey Wolf Therapeutics Limited (GB) 2023-02-02 WO disclosed
WO-2023007188-A1 PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS Grey Wolf Therapeutics Limited (GB) 2023-02-02 WO disclosed
US-20230000851-A1 ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2023-01-05 US disclosed
US-20220347176-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2022-11-03 US disclosed
EP-4058429-A1 ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2022-09-21 EP disclosed
EP-3966196-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2022-03-16 EP disclosed
EP-3883650-A1 COMPOUNDS Grey Wolf Therapeutics Limited (GB) 2021-09-29 EP disclosed
CN-113056305-A Compound (I) 格雷沃尔夫治疗有限公司 2021-06-29 CN disclosed
WO-2021094763-A1 ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2021-05-20 WO disclosed
WO-2020225569-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2020-11-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240366595-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS CHP1, ERAP1, QSOX1 ALDH1A1 1477/4885L3MBTL1 3192/4885SMN1; SMN2 4417/4885
US-20220347176-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS ERAP1, CHP1, QSOX1 ALDH1A1 1546/4885L3MBTL1 1197/4885SMN1; SMN2 4305/4885
US-12377084-B2 ERAP1 modulators ERAP1, NR1I3, HRH4 ALDH1A1 2660/4885L3MBTL1 4128/4885SMN1; SMN2 4606/4885
US-20230064417-A1 COMPOUNDS H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HRH4, CBR3 ALDH1A1 2613/4885L3MBTL1 3697/4885SMN1; SMN2 3059/4885
US-12023333-B2 Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators ERAP1, CHP1, QSOX1 ALDH1A1 1431/4885L3MBTL1 2457/4885SMN1; SMN2 4365/4885
US-20230000851-A1 ERAP1 MODULATORS ERAP1, NR1I3, HRH4 ALDH1A1 2660/4885L3MBTL1 4128/4885SMN1; SMN2 4606/4885
US-12485169-B2 Compounds SLC10A1, VHL, CFTR ALDH1A1 276/4885L3MBTL1 4696/4885SMN1; SMN2 378/4885
US-20240376046-A1 PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS ERAP1, XPO1, RRP15 ALDH1A1 2435/4885L3MBTL1 3137/4885SMN1; SMN2 3512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.