Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896836 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL5069835 | 0.79 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL8894968 | 0.73 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8343845 | 0.71 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8347213 | 0.70 | PTGS2 (0.55) | PTGS2PTGS1SYK | |
| SCHEMBL5594003 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL5069832 | 0.69 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8923114 | 0.67 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL8347217 | 0.67 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL12258055 | 0.64 | PKM (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997038986-A1 | SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES AS PRODRUGS OF COX-2 INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-23 | — | — | WO | disclosed |