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SCHEMBL889791

SCHEMBL889791

NC(=O)N1CCc2c1ccc1[nH]c(C(=O)N3CCc4c3ccc3[nH]c(C(=O)N5CCc6c5ccc5[nH]c(C(=O)Oc7c(F)c(F)cc(F)c7F)cc65)cc43)cc21

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 3/20 0.39
▸ POLB P06746 2/20 0.39
▸ NPC1 O15118 3/20 0.38
▸ HRH4 Q9H3N8 7/20 0.37
▸ MAPT P10636 1/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34
▸ BTK Q06187 2/20 0.33
▸ CFD P00746 1/20 0.33
▸ GAA P10253 1/20 0.32
▸ NOTUM Q6P988 1/20 0.32
▸ KIF11 P52732 1/20 0.32
▸ BAZ2B Q9UIF8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13783567 1.00 RAB9A (0.39) RAB9APOLBNPC1HRH4MAPT
SCHEMBL3494654 0.96 HRH4 (0.35) RAB9APOLBNPC1HRH4MAPT
SCHEMBL13183290 0.91 HRH4 (0.39) RAB9APOLBNPC1HRH4MAPT
SCHEMBL13003091 0.88 RAB9A (0.36) RAB9APOLBNPC1HRH4MAPT
SCHEMBL14356126 0.87 RAB9A (0.37) RAB9APOLBNPC1HRH4MAPT
SCHEMBL20764389 0.86 RAB9A (0.41) RAB9APOLBNPC1HRH4MAPT
SCHEMBL889973 0.85 RAB9A (0.43) RAB9APOLBNPC1HRH4MAPT
SCHEMBL20764323 0.83 HRH4 (0.46) RAB9APOLBNPC1HRH4MEN1
SCHEMBL13183208 0.83 HRH4 (0.39) POLBHRH4GAAKIF11BAZ2B
SCHEMBL888599 0.83 GPR119 (0.39) HRH4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210155657-A1 SEPARATION AND ISOLATION OF NUCLEIC ACIDS USING AFFINITY LIGANDS BOUND TO A SOLID SURFACE EMP BIOTECH GMBH (DE) 2021-05-27 — — US disclosed
US-9334495-B2 Minor groove binder (MGB)-oligonucleotide miRNA antagonists ELITECHGROUP B.V. (NL) 2016-05-10 — — US disclosed
US-9334495-B2 Minor groove binder (MGB)-oligonucleotide miRNA antagonists ELITECHGROUP B.V. (NL) 2016-05-10 — — US disclosed
US-8980855-B2 Minor groove binder (MGB)-oligonucleotide miRNA antagonists ELITECH HOLDING B.V. (NL) 2015-03-17 — — US disclosed
US-8980855-B2 Minor groove binder (MGB)-oligonucleotide miRNA antagonists ELITECH HOLDING B.V. (NL) 2015-03-17 — — US disclosed
US-8465921-B2 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders ELITECH HOLDING B.V. (NL) 2013-06-18 — — US disclosed
US-8465921-B2 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders ELITECH HOLDING B.V. (NL) 2013-06-18 — — US disclosed
US-20120245219-A1 MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS DHARMACON, INC. (US) 2012-09-27 — — US disclosed
US-20120245219-A1 MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS DHARMACON, INC. (US) 2012-09-27 — — US disclosed
US-20110275070-A1 HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS EPOCH PHARMACEUTICALS, INC. 2011-11-10 — — US disclosed
US-20110172289-A1 MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS ELITECH HOLDING B.V. 2011-07-14 — — US disclosed
US-20110172289-A1 MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS ELITECH HOLDING B.V. 2011-07-14 — — US disclosed
US-7794945-B2 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders ELITECH HOLDING B.V. (NL) 2010-09-14 — — US disclosed
US-7794945-B2 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders ELITECH HOLDING B.V. (NL) 2010-09-14 — — US disclosed
US-7556923-B1 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders EPOCH BIOSCIENCES, INC. (US) 2009-07-07 — — US disclosed
US-7556923-B1 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders EPOCH BIOSCIENCES, INC. (US) 2009-07-07 — — US disclosed
US-20090048427-A1 HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS EPOCH BIOSCIENCES, INC. (US) 2009-02-19 — — US disclosed
US-20090048427-A1 HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS EPOCH BIOSCIENCES, INC. (US) 2009-02-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120245219-A1 MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS ZFR, SLIRP, CNBP RAB9A 2713/4885POLB 43/4885NPC1 2494/4885
US-20210155657-A1 SEPARATION AND ISOLATION OF NUCLEIC ACIDS USING AFFINITY LIGANDS BOUND TO A SOLID SURFACE ADAR, SSBP1, POLRMT RAB9A 4778/4885POLB 105/4885NPC1 3996/4885
US-20090048427-A1 HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS DDB1, LIG3, MSH2 RAB9A 4496/4885POLB 14/4885NPC1 2945/4885
US-20110172289-A1 MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS ZFR, SLIRP, CNBP RAB9A 2713/4885POLB 43/4885NPC1 2494/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.