SCHEMBL8900417

SCHEMBL8900417

CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(C)c2C(=S)OCC)cc1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 4/20 0.68
AGTR1 P30556 2/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8898998 0.95 AGTR2 (0.69) AGTR2AGTR1
SCHEMBL8899458 0.91 AGTR2 (0.73) AGTR2AGTR1
SCHEMBL8902745 0.90 AGTR1 (0.57) AGTR2AGTR1
SCHEMBL8971357 0.87 AGTR2 (0.58) AGTR2AGTR1
SCHEMBL8900505 0.87 AGTR2 (0.74) AGTR2AGTR1
SCHEMBL8970010 0.86 AGTR2 (0.60) AGTR2AGTR1
SCHEMBL8904335 0.85 AGTR2 (0.65) AGTR2AGTR1
SCHEMBL8899395 0.85 AGTR2 (0.83) AGTR2AGTR1
SCHEMBL8902817 0.84 AGTR1 (0.59) AGTR2AGTR1
SCHEMBL8903177 0.84 AGTR1 (0.53) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6009572-A None JP disclosed
US-5612365-A CARDIOVASCULAR DISORDERS AND COGNITIVE ACTIVATORS HOECHST AKTIENGESELLSCHAFT (DE) 1997-03-18 US disclosed
US-5604251-A Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors HOECHST AKTIENGESELLSCHAFT (DE) 1997-02-18 US disclosed
US-5475004-A Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease HOECHST AKTIENGESELLSCHAFT (DE) 1995-12-12 US disclosed
US-5468764-A Administering to a mammal an azole derivative HOECHST AKTIENGESELLSCHAFT (DE) 1995-11-21 US disclosed
JP-H069572-A IMIDAZOLE DERIVATIVE HAVING BIPHENYLSULFONYLUREA OR BIPHENYLSULFONYLURETHANE SIDE CHAIN, ITS PREPARATION AND ITS USE HOECHST AG 1994-01-18 JP disclosed